As the Emanuel brothers explained to Charlie Rose back in 2008, there was a healthy level of competition and debate in their household growing up. It seems to have served them well, though; each brother has become tremendously successful in his own field.

Chicagoans may be most familiar with Mayor Rahm Emanuel, but younger brother Ari is a Hollywood super-agent so notorious that one of the characters on the TV show, Entourage, is based on him. Rahm’s older brother, Ezekiel, is a prominent bioethicist who served as a special healthcare advisor to the Obama administration. Here’s what Rahm told Charlie Rose about his older brother in 2008:

“Ari and I always say this, this is going to be the guy that gets the Nobel Prize, there’s no doubt about it in my view. Zeke is one of the brightest people in medicine and thinking about it.”

Dr. Emanuel is currently the Diane v.S. Levy and Robert M. Levy University Professor and vice provost for global initiatives at the University of Pennsylvania.

Tune into Afternoon Shift with Steve Edwards just after 2:00 p.m. today, when host Steve Edwards talks chats with the eldest Emanuel brother to find out more about “Growing up Emanuel” (also the name of his forthcoming book) and his career in medicine.