ICYMI: CRISPR

To test several CRISPR variations, scientists at the Gladstone Institutes developed replicas of the faulty retinal cells of Jim Johnsen, father of Nerdette host Greta Johnsen. The Johnsen family's faulty cells are their retinal pigment epithelium or RPE cells. The dark material seen here are RPE cells. (Photo courtesy of the University of California, San Francisco)
To test several CRISPR variations, scientists at the Gladstone Institutes developed replicas of the faulty retinal cells of Jim Johnsen, father of Nerdette host Greta Johnsen. The Johnsen family's faulty cells are their retinal pigment epithelium or RPE cells. The dark material seen here are RPE cells. (Photo courtesy of the University of California, San Francisco)
To test several CRISPR variations, scientists at the Gladstone Institutes developed replicas of the faulty retinal cells of Jim Johnsen, father of Nerdette host Greta Johnsen. The Johnsen family's faulty cells are their retinal pigment epithelium or RPE cells. The dark material seen here are RPE cells. (Photo courtesy of the University of California, San Francisco)
To test several CRISPR variations, scientists at the Gladstone Institutes developed replicas of the faulty retinal cells of Jim Johnsen, father of Nerdette host Greta Johnsen. The Johnsen family's faulty cells are their retinal pigment epithelium or RPE cells. The dark material seen here are RPE cells. (Photo courtesy of the University of California, San Francisco)

ICYMI: CRISPR

Greta Johnsen, host of Nerdette, has a rare genetic disease. CRISPR might be able to fix it.

As a four-year old in Juneau, Alaska, Greta was diagnosed with an eye condition known as "Best disease." That name is somewhat of a misnomer in that "Best disease" causes premature macular degeneration — but curiously it happens to be among the best diseases for experimenting with CRISPR, a genetic engineering tool that can be used to edit DNA.

CRISPR has been in the news a lot lately (Google it) so we're rebroadcasting this very special episode, one that follows the story of Greta, her father (who also has Best disease), and Dr. Bruce Conklin, a scientist who's currently developing a CRISPR system to inject into some Johnsen family eyeballs. 

Plus, you can't have a conversation about experimental gene editing without discussing the ethical implications of making irreversible changes to human evolution. 

“We’d be permanently altering the course of evolution if we decide that we think it’s OK to edit human embryos," says Megan Hochstrasser, a science communications manager and CRISPR expert. "Is that something we want to be able to do as a society?”

That's a great question. Let's talk about it.