(Photos in slideshow by Andrew Gill/WBEZ)
Chicago's quiet bats came to life in the fourth inning with three runs, sparked by a home run from Kris Bryant and four more hits that followed that allowed the Cubs to hold on to the dream of winning their first World Series in 108 years.
On the brink of elimination, Cubs ace starter Jon Lester turned in a strong six innings to reignite roars from the home crowd and flame-throwing reliever Aroldis Chapman did a yeoman's job in registering the last eight outs to preserve the must win.
"It didn't feel like an elimination game," said 24-year-old third baseman Bryant. "Jon (Lester) doing his thing, Chapman coming in for eight outs. That was an unbelievable win."
Cubs first baseman Anthony Rizzo, who followed Bryant's blast with a double off the wall in right and came around to score, had a different take on the mounting tension in the win-or-go-home thriller.
"High anxiety and a lot of deep breaths," Rizzo said about dealing with the pressure. "Every pitch gets bigger and bigger as the game goes on.
"Great win, to set these fans off with a win. Now we get to go back to Cleveland and take care of business."
Chapman, whose longest outing this season was 2 1/3 innings, was asked to go one out longer when Cubs manager Joe Maddon brought him in with out in the seventh and a man on first and the score 3-2.
But the Cuban-born reliever poured his 100 mph-plus fastballs in to overpower the Indians, striking out four on his way to the critical save.
Lester, who yielded two runs on four hits while striking out five, registered the victory. Cleveland starter Trevor Bauer took the loss, his second of the Series.
Before the game, spirits did not seem as high among fans compared to the first two games played in Chicago, as revelers seemed subdued, wary of a third straight loss at Wrigley.
But by the end, the crowd was roaring and after Jose Ramirez struck out to end the game, fans inside and outside Wrigley stood and sang the team song with the title dream still alive.
"I'm feeling amazing," Nicole Herrington, who lives a few blocks from the stadium with her husband and four-month-old boy, told Reuters. "We can't believe that they are not (going to win).
"It's been unbelievable. One hundred and three wins in the regular season. They got to take it in Cleveland. They have to take it in Cleveland.
"How can we not win it now?"
Chicago's Jake Arrieta, the Game Two winner for the Cubs, is scheduled to start Game Six on Tuesday against Josh Tomlin, with a Game Seven to be played in Cleveland on Wednesday if needed.